Biochemical mechanisms and clusters of damage for high-let radiation
نویسندگان
چکیده
منابع مشابه
Does Hze Radiation-induced Dna Damage Differ from Low-energy High Let Radiation Damage?
METHODS We have used 1 GeV/u and 600 MeV/u iron ions at NSRL, 300 kVp X-rays and 25 MeV/u nitrogen ions from the 88” cyclotron at Lawrence Berkeley National Laboratory. For measurements of DNA double-strand breaks we are using pulsed-field gel electrophoresis (PFGE) with a dual label technique that includes control samples in each lane and the use of the most sensitive part of the FAR vs dose c...
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The number of tumor patients treated with carbon ions is increasing worldwide and even new therapy centres are planned. Therefore it is important to get a better understanding of high-LET particle induced DNA damage. It has been known for several years that DNA double strand breaks (DSBs) evoked by particle radiation are generally more slowly repaired than breaks induced by photon irradiation. ...
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Melvyn Folkard, Gray Cancer Institute, UK Barry D. Michael, Gray Cancer Institute, UK Kevin M. Prise, Gray Cancer Institute, UK Aloke Chatterjee, Lawrence Berkeley National Laboratory, Berkeley, CA Leslie Braby, Texas A&M University, College Station, TX David Brenner, Columbia University, New York, NY Roberto Cherubini, INFN, Legnaro, Italy Dieter Frankenberg, Göttingen, Germany Mark Hill, MRC,...
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چکیده هدف اصلی از طراحی لرزه ای تامین ایمنی جانی در هنگام وقوع زلزله و تعمیر پذیر بودن سازه خسارت دیده، پس از وقوع زلزله است. تجربه زلزله های اخیر نشان داده است که ساختمان های طراحی شده با آیین نامه های مبتنی بر نیرو از نظر محدود نمودن خسارت وارده بر سازه دقت لازم را ندارند. این امر سبب پیدایش نسل جدید آیین نامه های مبتنی بر عملکرد شده است. در این آیین نامه ها بر اساس تغییرشکل های غیرارتجاعی ...
15 صفحه اولMechanisms for the biological effectiveness of high-LET radiations.
Radiations of high linear energy transfer (LET) have long been known to have greater biological effectiveness per unit dose than those of low LET, for a wide variety of biological effects. However, values of relative biological effectiveness depend considerably on the biological system and in some instances the values are clearly below unity. The differences between high- and low-LET radiations...
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ژورنال
عنوان ژورنال: Advances in Space Research
سال: 1992
ISSN: 0273-1177
DOI: 10.1016/0273-1177(92)90087-e